Geoff A. Parker

The pre-B-cell receptor induces silencing of VpreB and k5 transcription

Mathew J Parker, Steve Licence, Lena Erlandsson, Gunther R Galler, Lyubomira Chakalova, Cameron S Osborne, Geoff Morgan, Peter Fraser, Hassan Jumaa, Thomas H Winkler, Jane Skok and Inga-Lill Mårtensson* Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, UK, Hematopoiesis Unit, Nikolaus-FiebigerCenter, Erlangen, Germany, Laboratory of Chromatin and Gene Expres...

Undiscovered Worlds – Towards a Framework for Real-Time Procedural World Generation

With advances in computer hardware, 3D game worlds are becoming larger and more complex. Consequently the development of game worlds becomes increasingly time and resource intensive. This paper presents a framework for generation of entire virtual worlds using procedural generation. The approach is demonstrated with the example of a virtual city.

THE PERSIANS. LOST CIVILIZATIONS Geoffrey Parker and Brenda Parker, Reaktion Book, 2017, 208 pages

Prolonged hypotension following elective stenting of an internal carotid artery stenosis.

We report a case of a 72-year-old man who had undergone elective stenting of an asymptomatic high grade stenosis of the proximal left internal carotid artery. The indication was progression of the stenosis over a 3 year period despite receiving maximal medical therapy, and patient preference for stenting over endarterectomy. He became profoundly hypotensive in the immediate post-stent period an...

Toxoplasma gondii: prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire, UK, two species of bats (Pipistrellus pipistrellus and Pipistrellus pygmaeus) were tested using a highly sensitive SAG1-PCR method specific for detection of T. gondii DNA (n=77; 7...

Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging.

This article reviews the application of dynamic contrast-enhanced magnetic resonance imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is placed on how variation in image acquisition and analysis affects the meaning and use of derived variables. We then review the potential for future developments, with particular reference to the application of dynami...